StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...
Free

Comprehensive High-Throughput Arrays for Relative Methylation - Article Example

Cite this document
Summary
This article "Comprehensive High-Throughput Arrays for Relative Methylation" attempts to reveal that the genetics behind the carcinogenic cells and the concept of epigenetic is the same. It is vital for having a piece of in-depth knowledge in the field of genetics…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER98.3% of users find it useful
Comprehensive High-Throughput Arrays for Relative Methylation
Read Text Preview

Extract of sample "Comprehensive High-Throughput Arrays for Relative Methylation"

The paper “Comprehensive High-Throughput Arrays for Relative Methylation and Cancer Genetics, Epigenetics - Two Sides of the Same Coin" is a spectacular example of a literature review on science. Respectively, the authors commented that genetic alteration and epigenetic has been considered as two different mechanisms contributing to carcinogenesis.

However, their recent study revealed that these two genetic factors in the field of carcinogenesis are the same. The article of Irizarry, Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen, and Feinberg (780) suggested that their research objective of discovering the effective tool to identify the genomic locations has been a major success in the field of genetic alteration and epigenetic. This new tool shows nearly ‘100% sensitivity at 90% specificity with McrBC’. In addition, the new tool is termed as ‘Comprehensive high-throughput arrays for relative Methylation’ (CHARM).

IMPORTANT CONCLUSIONS The study of You and Jones (9) in the field of carcinogenesis and genetics revealed that cancer genetics and epigenetics are the same. The authors further conclude that genetic alteration, which is not inherent to the next generation, is the major factor that leads to the formation of carcinogenic cells or cancer. A similar cause is also notable from the epigenetic process that leads to mutation of the cells and finally causes cancer. In the experimental study of Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen, and Feinberg (780), a major conclusion has been drawn with regard to the effectiveness of CHARM.

CHARM is highly effective in determining genomic locations. The effectiveness of the tool is evident from the high sensitivity and specificity in identifying the locations of the genomes. Moreover, the researchers concluded that CHARM is a relatively inexpensive tool and is highly effective in determining genome width. Furthermore, the researchers determined that individual sample analysis could be executed with the assistance of this tool, wherein the sample has a high density. Evidence FOR CONCLUSIONS There is certain research evidence based upon which You and Jones (9) concluded their findings.

Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Compre Article, n.d.)
Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Compre Article. https://studentshare.org/biology/1860951-summary
(Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Compre Article)
Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Compre Article. https://studentshare.org/biology/1860951-summary.
“Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Compre Article”. https://studentshare.org/biology/1860951-summary.
  • Cited: 0 times

CHECK THESE SAMPLES OF Comprehensive High-Throughput Arrays for Relative Methylation

Systemic Lupus Erythematosus

The paper 'Systemic Lupus Erythematosus' looks at a remarkable disease in many aspects; the primary being it is not a single but a protean disease, affecting almost every organ of the body.... The disease is fatal and is manifested in form of multiple clinical symptoms.... ... ... ... The author explains that SLE is a chronic, inflammatory, prototypic, systemic autoimmune disease affecting connective tissues such as skin, joints along with kidney and serosal membranes....
7 Pages (1750 words) Essay

Current Methods of High-Throughput Expression Profiling in Normal and Disease States

DNA methylation which is important in the normal DNA function and gene expression can be used to detect the changes in the DNA leading to abnormal expression and disease.... Hyper-methylation and hypo-methylation have been associated with significant changes in some cells.... Hyper methylation has also been associated with Leukemia, Ovarian cancer and colorectal cancer (Baylin, 2005).... The varying magnitudes of methylation in the cells are associated with different stages of cancer development, and DNA methylation technique can be used to determine the exact stage (Costello et al, 2000)....
3 Pages (750 words) Essay

Role of Phytooestrogen in the Prevention of Breast Cancer

The paper "Role of Phytooestrogen in the Prevention of Breast Cancer" asserts that the breast cancer risk of BRCA1 carriers is found to increase in terms of earlier age at diagnosis in presence of polymorphic alterations in the androgen receptor gene or in the steroid hormone metabolism gene ABI1....
18 Pages (4500 words) Coursework

Histone H3 Lysine MethylationK Is Mediated by Set1 and H3s Requirement for Cell Growth and rDNA Silencing

This review has a summary of the research paper: “Histone H3 lysine methylation K is mediated by Set1 and H3's requirement for cell growth and rDNA silencing” and a brief conclusion that gives a perspective about the research paper.... The research paper has worked to show that the existence of H3K 4 di and tri methylation depends on Set1 and RBBP-5.... Completely different subsets of Set 1 seem to be a requirement for the H3 methylation present germ cells and lineages at different stages of development especially later in embryogenesis....
2 Pages (500 words) Research Paper

Competitive Inhibitor for Inhibiting the Methylation of Protein Phosphate 2a via LCMT-1

The paper "Competitive Inhibitor for Inhibiting the methylation of Protein Phosphate 2a via LCMT-1" discusses that the main goal of a PDB is to create a resource that is based on the most modern technology that facilitates the use and subsequent analysis of structural data.... A substantial amount of PP2A is usually in the methylated form and range from 70 to 93%, which depend on the particular method utilized in the evaluation of the level of methylation.... methylation of the PP2A is considered important for the binding process of the B subunits that commonly target PP2A for the differentiation of substrate and specific cellular compartments....
16 Pages (4000 words) Essay

DNA Methylation and Human Aging

This assignment "DNA methylation and Human Aging" focuses on human aging that was the main factor that led to the purpose of this study which was to establish if the DNA methylomes in newborns are different in older people those aged and in between old age and newborns.... In relation to methylation, CpG regions tend to have a high content of methylomes hence were the most suitable for the study.... 12- 16 Whole Genome bisulfite sequencing of all the samples: newborn, centenarian, and intermediate, was done to identify the methylation status....
2 Pages (500 words) Assignment

DNA Methylation Effects in Friedreich Ataxia (FRDA)

The aim of the paper 'DNA methylation Effects in Friedreich Ataxia (FRDA)' is to describe and analyze data from recent studies dedicated to the effects of DNA methylation in Friedreich ataxia.... This paper will analyze the possible effects of DNA methylation at the FRDA gene promoter in FRDA in two sets transgenic mouse tissues, one of which contains GAA repeat expansion mutations, whilst the other does not....
20 Pages (5000 words) Book Report/Review

The Relative Contribution of Genetics and Epigenetics to Schizophrenia

Epigenetics focuses on Histone, HDAC, and DNA methylation.... Epigenetics involves modification of the histone, methylation of the patient's DNA.... The paper "The relative Contribution of Genetics and Epigenetics to Schizophrenia" states that both genetics and epigenetics study can help in Schizophrenia ailment research.... he (relative) Contribution of Genetics/Epigenetics to the Schizophrenia AilmentGenetics indicates one offspring may inherit the traits of one or both parents....
7 Pages (1750 words) Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us